Bioteknologi : prinsip, konsep dan aplikasi

Penulis

  • Anita Ninasari Penulis
  • Deny Ismail Pellu Penulis
  • Oktora Susanti Penulis
  • Kurnia Anggraini Rahmi Penulis
  • Meri Helsiana Mata Penulis
  • Hamdanul Fain Penulis
  • Almira Fardani Lahay Penulis
  • Santosa Pradana Putra Setya Negara Penulis
  • Triayu Rahmadiah Penulis
  • Muhammad Kholiqul Amiin Penulis
  • Leni Handayani Penulis
  • Nevada JM Nanulaitta Penulis

Kata Kunci:

Bioteknologi : prinsip, konsep dan aplikasi

Abstrak

Buku “Bioteknologi: Konsep, Prinsip, dan Aplikasi” membahas bioteknologi sebagai ilmu multidisiplin yang memanfaatkan organisme hidup, sistem biologis, dan komponen hayati untuk menghasilkan produk serta jasa yang bermanfaat bagi manusia. Buku ini disusun secara sistematis, mulai dari pengertian, sejarah, ruang lingkup, cabang bioteknologi, hingga dasar-dasar ilmu pendukung seperti biologi sel, genetika, mikrobiologi, dan biokimia. Pembahasan dilanjutkan dengan pemanfaatan mikroorganisme, bahan hayati, proses fermentasi, bioteknologi konvensional dan modern, serta teknologi mutakhir seperti rekayasa genetika, DNA rekombinan, kultur jaringan, bioinformatika, dan biologi sintetik. Buku ini juga menguraikan aplikasi bioteknologi dalam bidang pangan, pertanian, perikanan, kesehatan, industri, energi, dan lingkungan. Selain itu, dibahas aspek bioetika, biosafety, biosecurity, dan regulasi. Dengan bahasa ilmiah yang komunikatif, buku ini cocok menjadi buku ajar dan referensi bagi mahasiswa, dosen, peneliti, praktisi, serta pembaca umum untuk memahami bioteknologi secara menyeluruh.

Referensi

A. Sahoo et al, (2025). Cellular engineering strategies for soluble and secretory recombinant human insulin production in pseudomonas fluorescens and batch bioreactor study. J. Biotechnol.

A. Sahoo et al., (2024). Production of recombinant human insulin from a promising Pseudomonas fluorescens cell factory and its kinetic modeling Int. J. Biol. Macromol.

Adamu, S. M., et al. (2016). Biotechnology as a Cradle of Scientific Development. DOI: https://doi.org/10.9734/JABB/2016/29092 ISSN: 2394-1081 (Journal JABB).

Adrianto, H., Ulinniam, Eny Wahyuning Purwanti, Yusal, M. S., Widyastuti, D. A., Sutrisno, E., Tamaela, K. A., Dailami, M., Purbowati, R., Angga, L. O., Hasibuan, A. K. H., Hariri, M. R., Nendissa, D. M., Nendissa, S. J., Noviantari, A., & Chrisnawati, L. (2021). BIOTEKNOLOGI. https://www.researchgate.net/publication/352349743_Bioteknologi

Amarakoon, I. I., Hamilton, C.-L., Mitchell, S. A., Tennant, P. F., Roye, M. E., Byfield, G., Smith, K. N., & Delgoda, R. (2017). Biotechnology. In S. Badal & R. Delgoda (Eds.), Pharmacognosy: Fundamentals, Applications and Strategies (pp. 549–563). Academic Press (Elsevier). https://doi.org/https://doi.org/10.1016/B978-0-12-802104-0.00028-7

Antar, S. A., Ashour, N. A., Sharaky, M., Khattab, M., Ashour, N. A., Zaid, R. T., Joo, E., Elkamhawy, A., & Al-

karmalawy, A. A. (2023). Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments. Biomedicine & Pharmacotherapy, 168, 115734. https://doi.org/10.1016/j.biopha.2023.115734 Asiegbu, F. O. (2025). Biotechnology: History, processes, and prospects in forestry. In Forest Microbiology (pp. 3-14). Academic Press.

Badal, S., Byfield, G., Smith, K. N., & Delgoda, R. (2017). Biotechnology. In Pharmacognosy: Fundamentals, Applications and Strategies (pp. 549–563). Academic Press (Elsevier). https://doi.org/10.1016/B978-0-12-802104-0.00028-7

Barney, N., & Lewis, S. (2022). biotechnology (biotech). Techtarget.Com. https://www.techtarget.com/whatis/definition/biotechnology#:~:text=Biotechnology is the use of, and the discovery of fermentation

Barragán-Ocaña, A., Sánchez-Ramírez, E., Aguilar, C. N., & Rodríguez-Herrera, R. (2020). Biotechnology and Bioprocesses : Their Contribution to Sustainability. Processes, 8(4), 1–11. https://doi.org/10.3390/pr8040436

Barrangou, R., & Marraffini, L. A. (2014). Review CRISPR-Cas Systems : Prokaryotes Upgrade to Adaptive Immunity. Molecular Cell, 54(2), 234–244. https://doi.org/10.1016/j.molcel.2014.03.011

Book biotechnology (biotech) By Nick Barney, Technology Writer Sarah Lewis Published: Nov 01, 2022 What is biotechnology? Biotechnology is the use of biology to

develop new products, methods and organisms intended to improve human health and society.

Britannica. (2026). biotechnology. Britannica.Com. https://www.britannica.com/technology/biotechnology

Buchholz, K., & Collins, J. (2013). The roots—a short history of industrial microbiology and biotechnology. Appl Microbiol Biotechnol, 9(97), 3747–3762. https://doi.org/10.1007/s00253-013-4768-2

Cossar, D. (2001). Development of Fermentation Process for rDNA Products. Current Opinion in Drug Discovery & Development, 4(6), 756–759.

Daniell, H., Singh, R., Mangu, V., Nair, S. K., Wakade, G., & Balashova, N. (2023). Affordable Oral Proinsulin Bioencapsulated in Plant Cells Regulates Blood Sugar Levels Similar to Natural Insulin. Biomaterials, 298. https://doi.org/10.1016/j.biomaterials.2023.122142

Demain, A. L. (2000). Microbial Biotechnology. Trends in Biotechnology, 18(1), 26–31. https://doi.org/10.1016/S0167-7799(99)01400-6

Doudna, J. A., & Charpentier, E. (2014). Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Science, 346(6213). https://doi.org/10.1126/science.1258096

El-Gewely, M. R. (1996). Scope. Biotechnology Annual Review, 2(v). https://doi.org/10.1016/S1387-2656(08)70003-6

Fahrudin, F.A., & Fahrudin, F.I. (2024). Food Biotechnology in Indonesia: Obstacles and Prospects in the Future. International Journal of Research and Innovation in Applied Science, IX(IX), 170–174. DOI: https://doi.org/10.51584/IJRIAS.2024.909015 .

Frazzetto, G. (2018). Biotechnology and the bioeconomy—Towards inclusive and sustainable industrial development. New Biotechnology, 40, 5–10. https://doi.org/10.1016/j.nbt.2017.06.005

Fred O. Asiegbu, (2025). Volume 4: Biotechnology Applications in Forestry Volume 4 in Forest Microbiology 2025, Pages 3-14. Forest Microbiology, Chapter 1-Biotechnology: history, processes, and prospects in forestry Author links open overlay panel Fred O. Asiegbu.

Ghousepeer, G. D., Singh, P. A., & Pandey, R. P. (2024). History, Scope and Development of Biotechnology. In Introduction to Pharmaceutical Biotechnology, Volume 1 (Second Edition). IOP Publishing. https://doi.org/10.1088/978-0-7503-5382-3ch1

Gischa, S. (2022). Pengertian Bioteknologi, Sejarah, dan Ciri-ciri Utamanya. Kompas.Com. https://www.kompas.com/skola/read/2022/10/25/200000169/pengertian-bioteknologi-sejarah-dan-ciri-ciri-utamanya?page=all

Handayani, D., Agustina, E. P., Pratiwi, R. I., & Sari, V. O. (2026). PEMANFAATAN MIKROORGANISME DALAM BIOTEKNOLOGI KONVENSIONAL PADA INDUSTRI PANGAN. JURNAL MEDIA AKADEMIK (JMA), 4(5). https://doi.org/10.62281

Herdt, R. W. (2006). BIOTECHNOLOGY IN AGRICULTURE. Annu. Rev. Environ. Resour, 31(1), 265–95. https://doi.org/10.1146/annurev.energy.31.031405.091314

Hermantara, R. (2023). CRISPR-Cas9: A Story of Discovery, Innovation, and Revolution in Genome Editing.

Indonesian Journal of Life Sciences. https://doi.org/10.54250/ijls.v6i01.197

Insani, T. S. N. (2022). BIOREMEDIASI. Jurnalpost.Com. https://jurnalpost.com/bioremediasi/40655/

iScience. (2025). Socio-economic and environmental sustainability of biomanufactured food and agricultural products. DOI: https://doi.org/10.1016/j.isci.2025.114624 ISSN: 2589-0042.

Jinek, M., Chylinski, K., Hauer, I. F. M., Doudna, J. A., & Charpentier, E. (2012). A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity. Science, 337(6096), 816–821. https://doi.org/10.1126/science.1225829

Journal of Biotechnology. Elsevier. ISSN: 0168-1656 https://www.sciencedirect.com/journal/journal-of-biotechnology.

Journal of Environmental Management. (2025). Insights into Microalgal Biotechnology: Current Applications, Key Challenges, and Future Prospects. DOI: https://doi.org/10.1016/j.jenvman.2025.127263 ISSN: 0301-4797.

Journal of Environmental Management. (2025). Insights into Microalgal Biotechnology: Current Applications, Key Challenges, and Future Prospects. DOI: https://doi.org/10.1016/j.jenvman.2025.127263 ISSN: 0301-4797.

Jurnal Bioteknologi dan Biosains Indonesia (BRIN) ISSN: 2548-611X https://ejurnal.brin.go.id/JBBI.

Jurnal Bioteknologi dan Biosains Indonesia (BRIN) ISSN: 2548-611X. https://ejurnal.brin.go.id/JBBI.

Jurnal Bioteknologi dan Biosains Indonesia (BRIN). ISSN: 2548-611X. https://ejurnal.brin.go.id/JBBI

Kusrini, E., Whulanza, Y., & Budiyanto, M. A. (2022). Discovery and Biotechnology for the Better of Humanity and Environmental in Asia Region. International Journal of Technology, 13(8), 1607–1611. https://doi.org/10.14716/ijtech.v13i8.6291

LibreTexts. (2024). Introduction to Biotechnology. https://bio.libretexts.org (Biology LibreTexts).

M. Zieliński et al, Marraffini, L.A., (2015). CRISPR-Cas immunity in prokaryotes. Nature, 526(7571), pp.55–61. Available at: http://www.nature.com/doifinder/10.1038/nature15386. National Research Council, Policy, Global Affairs, Security, Cooperation, Committee on Research Standards, & Practices to Prevent the Destructive Application of Biotechnology. (2004). Biotechnology research in an age of terrorism.

Oost, J. Van Der, & Patinios, C. (2023). The genome editing revolution. Trends in Biotechnology, 41(3), 396–409. https://doi.org/10.1016/j.tibtech.2022.12.022

P.K. Das et al. (2022). Current status, and the developments of hosts and expression systems for the production of recombinant human cytokines Biotechnol. Adv.

P.K. Das et al. (2024). Recombinant monoclonal antibody production in yeasts: challenges and considerations. Int. J. Biol. Macromol. (2024).

P.K. Das et al. Pangkahila, W. (2011). Anti-Aging: Tetap Muda dan Sehat. PT Kompas Media Nusantara. Jakarta.

Prasetiawati, R. (2025). CRISPR, Synthetic Biology, and Beyond: Charting the Future of Molecular

Biotechnology. Jurnal Sains MIPA Indonesia. DOI: https://doi.org/10.61978/jsmi.v1i1.552.

Production of recombinant human insulin from a promising Pseudomonas fluorescens cell factory and its kinetic modeling

Puetz, J., & Wurm, F. M. (2019). Recombinant Proteins for Industrial versus Pharmaceutical Purposes: A Review of Process and Pricing. Processes, 1(8), 476. https://doi.org/10.3390/pr7080476

Putri, V. K. M. (2022). Pengertian Bioteknologi dan Ciri-cirinya. Kompas.Com. https://www.kompas.com/skola/read/2022/04/08/123000769/pengertian-bioteknologi-dan-ciri-cirinya

Rachman, A., et al. (2023). Synthetic Biology in Indonesia: Potential and Projection in a Country with Mega Biodiversity. Biotechnology Notes, 4, 41–48. DOI: https://doi.org/10.1016/j.biotno.2023.02.002.

Ran, F.A. et al., 2013. Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity. Cell, 154(6), pp.1380–1389. Available at: http://linkinghub.elsevier.com/retrieve/pii/S0092867413010155.

Sahm, H., Eggeling, L., & Graaf, A. A. de. (1999). Whole microbial cell processes for manufacturing amino acids, vitamins or ribonucleotides. Current Opinion in Biotechnology, 10(6), 604–608. https://doi.org/10.1016/S0958-1669(99)00041-5

Satrio, A., et al. (2025). Sejarah Perkembangan Ilmu Genetika. Didaktik: Jurnal Ilmiah PGSD STKIP Subang. DOI: https://doi.org/10.36989/didaktik.v11i04.9520.

Schürrle, K. (2020). History, Current State, and Emerging Applications of Industrial Biotechnology. In M.

Fröhling & M. Hiete (Eds.), Sustainability and Life Cycle Assessment in Industrial Biotechnology (Advances i). Springer, Cham. https://doi.org/10.1007/10_2018_81

ScienceDirect Topics. (2022). Biotechnology Overview.

ScienceDirect. (2025). Biotechnology: History and Prospects. DOI: https://doi.org/10.1016/B978-0-443-21903-0.00002-3 (ScienceDirect).

Sheldon, R.A., & Woodley, J.M. (2018). Role of biocatalysis in sustainable chemistry. Biotechnology Advances. DOI: https://doi.org/10.1016/j.biotechadv.2020.107520.

Singh, P., Kumar, V., Kumar, A., Singh, N., Yadav, A. N., & Singh, D. P. (2023). Prospects of Biotechnology for Productive and Sustainable Agro-Environmental Growth. In Advanced Microbial Techniques in Agriculture, Environment, and Health Management (pp. 83–97). Elsevier. https://doi.org/10.1016/B978-0-323-91643-1.00015-6

Song, G., Jia, M., Chen, K., Kong, X., Khattak, B., Xie, C., Li, A., & Mao, L. (2016). ScienceDirect CRISPR / Cas9 : A powerful tool for crop genome editing. The Crop Journal, 4(2), 75–82. https://doi.org/10.1016/j.cj.2015.12.002

Soozanipour, A., Ejeian, F., Boroumand, Y., Rezayat, A., Moazzam, P., & Moradi, S. (2023). Biotechnological Advancements Towards Water, Food and Medical Healthcare: A Review. Chemosphere, 312(1), 137185. https://doi.org/10.1016/j.chemosphere.2022.137185

Stryjewska, A., Kiepura, K., Librowski, T., & Lochyñski, S. (2013). Biotechnology and genetic engineering in the new drug development . Part I . DNA technology and

recombinant proteins. Pharmacological Reports, 65(5), 1075–1085. https://doi.org/10.1016/S1734-1140(13)71466-X

Sun, H., Saeedi, P., Karuranga, S., Pinkepank, M., Ogurtsova, K., Duncan, B. B., Stein, C., Basit, A., Chan, J. C. N., Mbanya, J. C., Pavkov, M. E., Ramachandaran, A., Wild, S. H., James, S., Herman, W. H., Zhang, P., Bommer, C., Kuo, S., Boyko, E. J., & Magliano, D. J. (2022). IDF Diabetes Atlas: Global, Regional and Country-Level Diabetes Prevalence Estimates for 2021 and Projections for 2045. Diabetes Research and Clinical Practice, 183. https://doi.org/10.1016/j.diabres.2021.109119

Suwanto, A. (1998). Bioteknologi Molekuler: Mengoptimalkan Manfaat Keanekaan Hayati melalui Teknologi DNA Rekombinan. Hayati: Journal of Biosciences (Hayati), 5(1), 25–28.

Todaka D, Shinozaki K, & Yamaguchi-Shinozaki K. (2017): Recent advances in the dissection of droughtstress regulatory networks and strategies for development of droughttolerant transgenic rice plants. Frontiers in plant science, 6, 84.

Trends in Biotechnology. Cell Press/Elsevier. ISSN: 0167-7799 https://www.sciencedirect.com/journal/trends-in-biotechnology.

Van Beilen, J.B., & Poirier, Y. (2005). Biotechnology—a sustainable alternative for chemical industry. Biotechnology Advances, 23(7–8), 471–499. https://doi.org/10.1016/j.biotechadv.2005.03.004 Watson, J. D., & Crick, F. H. C. (1953). Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic

Acid. Nature, 171(4356), 737–738. https://doi.org/10.1038/171737a0

Yeung, A. W. K., mll `Nikolay T. Tzvetkov b, C., D, V. K. G., E, S. C. G., , Gorka Orive f, g, H., Günther K. Bonn i, J., K, B. F., L, A. B., , Thomas Efferth m, J. X. n, , Ana Sanches Silva o, P., Q, G. L. R., , Maria Daglia r, au, Maurizio Battino s, T., U, I. E. O., V, F. N., Michael Heinrich w, B. B. A. x, Y, M. D., Z, M. B., , Wolfram Weckwerth aa, A., Rudolf Bauer ac, George Perry ad, Edward A. Bayer ae, Lukas A. Huber af, ag, J.-L. W. ah, … Michael Ristow ar, A. G. A. (2019). Current research in biotechnology: Exploring the biotech forefront. Current Research in Biotechnology, 1, 34–40. https://doi.org/10.1016/j.crbiot.2019.08.003

Zhao, H., Baltz, R. H., Katz, L., Chen, Y. Y., Gonzalez, R., Peterson, T. C., Woude, G. F. V., & Keasling, J. D. (2018). Synthetic Biology Advances and Applications in the Biotechnology Industry: A Perspective. Journal of Industrial Microbiology and Biotechnology, 45(7), 449–461. https://doi.org/10.1007/s10295-018-2056-y

Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raff, M., Roberts, K., & Walter, P. (2015). Molecular biology of the cell (6th ed.). Garland Science.

Andalia, N., Dinata, G. F., Suanda, I. W., Arisandi, D. P., Utami, C. D., Putri, N. F., et al. (2025). Bioteknologi. CV Get Press Indonesia.

Berg, J. M., Tymoczko, J. L., Gatto, G. J., & Stryer, L. (2019). Biochemistry (9th ed.). W.H. Freeman.

Brown, T. A. (2016). Gene cloning and DNA analysis: An introduction (7th ed.). Wiley.

Chaplin, M. F., & Bucke, C. (1990). Enzyme technology. Cambridge University Press.

Cooper, G. M., & Hausman, R. E. (2019). The cell: A molecular approach (8th ed.). Sinauer Associates.

Doudna, J. A., & Charpentier, E. (2014). The new frontier of genome engineering with CRISPR-Cas9. Science, 346(6213), 1258096.

Hidayat, T. (2022). Bioteknologi dalam pertanian berkelanjutan. Jurnal AgroBiogen, 18(2), 95–104.

James, C. (2015). Global status of commercialized biotech/GM crops: 2015 (ISAAA Brief No. 51). International Service for the Acquisition of Agri-biotech Applications (ISAAA).

Karp, G. (2018). Cell and molecular biology: Concepts and experiments (8th ed.). Wiley.

Lestari, D., Sari, R., & Widodo, S. (2020). Aplikasi rekayasa genetika dalam bioteknologi modern. Jurnal Bioteknologi & Biosains Indonesia, 7(2), 101–110.

Lodish, H., Berk, A., Kaiser, C. A., Krieger, M., Scott, M. P., Bretscher, A., Ploegh, H., & Amon, A. (2021). Molecular cell biology (9th ed.). W.H. Freeman.

Madigan, M. T., Bender, K. S., Buckley, D. H., Sattley, W. M., & Stahl, D. A. (2021). Brock biology of microorganisms (16th ed.). Pearson.

Nelson, D. L., & Cox, M. M. (2021). Lehninger principles of biochemistry (8th ed.). W.H. Freeman.

Nielsen, J., & Keasling, J. D. (2016). Engineering cellular metabolism. Cell, 164(6), 1185–1197

Pollard, T. D., Earnshaw, W. C., Lippincott-Schwartz, J., & Johnson, G. T. (2017). Cell biology (3rd ed.). Elsevier.

Primrose, S. B., & Twyman, R. M. (2020). Principles of gene manipulation and genomics (9th ed.). Wiley-Blackwell.

Willey, J. M., Sherwood, L. M., & Woolverton, C. J. (2020). Prescott’s microbiology (11th ed.). McGraw-Hill Education.

Yuliani, R., et al. (2021). Peran mikroorganisme dalam bioteknologi. Jurnal Mikrobiologi Indonesia

Ahmed, M. H., Khan, M. M., Dutta, S., Rahman, M. F., Islam, M. S., Hosen, M. N., Hossain, M. S., Rahman, M. A., Sahil, M. S. H., Hira, T. T., Ifthesum, Rahaman, A., Rabbi, M. A., & Khaleda, L. (2026). Molecular Pharming: Advances, Applications, and Future Prospects in Biotechnology and Medicine. Engineering in life sciences, 26(3), e70075. https://doi.org/10.1002/elsc.70075

Badan Riset dan Inovasi Nasional. (2024, August 8). Pemerintah luncurkan Indonesian Biodiversity Strategy Action Plan (IBSAP) sebagai panduan pengelolaan keanekaragaman hayati. https://brin.go.id/press-release/120022/pemerintah-luncurkan-indonesian-biodiversity-strategy-action-plan-ibsap-sebagai-panduan-pengelolaan-keanekaragaman-hayati

Bhardwaj, S., Kumari, M., Chethan, T., Hosamani, M., Paul, M., Moirangthem, A., Dash, A. P., & Verma, S. (2025). Advances in micropropagation and tissue culture for horticultural crops: A review. Plant Cell Biotechnology and Molecular Biology, 26(11–12), 166–182. https://doi.org/10.56557/pcbmb/2025/v26i11-1210039

Chen, B., Slocombe, R. F., & Georgy, S. R. (2023). Advances in organoid technology for veterinary disease modeling. Frontiers in Veterinary Science, 10, Article 1234628. https://doi.org/10.3389/fvets.2023.1234628

Coherent Market Insights. (n.d.). Global animal biotechnology market. https://www.coherentmarketinsights.com/i

ndustry-reports/global-animal-biotechnology-market Engels, J. M. M., & Ebert, A. W. (2021). A Critical Review of the Current Global Ex Situ Conservation System for Plant Agrobiodiversity. II. Strengths and Weaknesses of the Current System and Recommendations for Its Improvement. Plants (Basel, Switzerland), 10(9), 1904. https://doi.org/10.3390/plants10091904

Fu, Y.-B. (2024). Will a plant germplasm accession conserved in a genebank change genetically over time? Frontiers in Plant Science, 15, Article 1437541. https://doi.org/10.3389/fpls.2024.1437541

Jiang, X., Ji, J., Yang, Q., Dou, Y., Li, Y., Yang, X., Liu, C., Dou, S., & Dong, L. (2025). Key Technologies of Synthetic Biology in Industrial Microbiology. Microorganisms, 13(10), 2343. https://doi.org/10.3390/microorganisms13102343 Kanth, K., Sanjay Mane, R., Deo Prasad, B., Sahni, S., Kumari, P., Quaiyum, Z., Kumar, S., Singh, A., & Kumar Chaudhary, R. (2025). Editing the Future: CRISPR/Cas9 for Climate-Resilient Crops. In Genetics. IntechOpen. https://doi.org/10.5772/intechopen.1009023

Kaur, N., Qadir, M., Francis, D. V., Alok, A., Tiwari, S., & Ahmed, Z. F. R. (2025). CRISPR/Cas9: A sustainable technology to enhance climate resilience in major staple crops. Frontiers in Genome Editing, 7, Article 1533197. https://doi.org/10.3389/fgeed.2025.1533197

Kumari, A., Sharma, L., Yadav, Y., Karma, A., Singh, J., & Arya, S. C. (2025). Biotechnological strategies for seed germplasm maintenance and plant genetic resource

conservation. In B. Roy, G. Shukla, V. Dunna, P. Sharma, & P. S. Shukla (Eds.), Advances in seed quality evaluation and improvement (pp. 379–403). Springer, Singapore. https://doi.org/10.1007/978-981-96-5178-8_15

Lee, C.-J., Nam, Y., Rim, Y. A., & Ju, J. H. (2026). Harnessing induced pluripotent stem cells and organoids for disease modeling and precision medicine. Stem Cell Research & Therapy, 17, Article 106. https://doi.org/10.1186/s13287-026-04906-9

Medina, D., & Azmi, M. R. (2024). Perlindungan sumber daya genetik dan pengetahuan tradisional dalam kerangka World Intellectual Property Organization (WIPO). Jurnal Das Sollen, 1(1), 162–177. Michán, C., & Ramos, J. L. (2025). Microbial Biotechnology as a Catalyst for a Better and More Sustainable World. Microbial biotechnology, 18(7), e70196. https://doi.org/10.1111/1751-7915.70196

Morawska-Kozłowska, M., Pitas, M., & Zhalniarovich, Y. (2025). Mesenchymal Stem Cells in Veterinary Medicine—Still Untapped Potential. Animals, 15(8), 1175. https://doi.org/10.3390/ani15081175 Multisanti, C. R., Celi, V., Dibra, A., Pintus, A., Calogero, R., Rizzo, C., & Faggio, C. (2025). Microbial Blue Bioprospecting: Exploring the Advances of Compounds Post-Discovery. Marine drugs, 23(10), 406. https://doi.org/10.3390/md23100406

Nurrahmah, D., & Nurhaliza, F. (2025). Model kultur tiga dimensi sel punca mesenkim: Kondisi terkini dan arah pengembangan. Insight of Biology, 1(2), 41–46. https://doi.org/10.70716/inbio.v1i2.279

Pasternak, T. P., & Steinmacher, D. (2024). Plant Growth Regulation in Cell and Tissue Culture In Vitro. Plants (Basel, Switzerland), 13(2), 327. https://doi.org/10.3390/plants13020327

Precedence Research. (2025, November 18). Animal biotechnology market size expected to reach USD 72.6 billion by 2034. GlobeNewswire. https://www.globenewswire.com/news-release/2025/11/18/3190220/0/en/Animal-Biotechnology-Market-Size-Expected-to-Reach-USD-72-6-Billion-by-2034.html Rampelotto, P. H., & Kolář, M. (2025). Trends in Microbiology 2024. Life (Basel, Switzerland), 15(1), 65. https://doi.org/10.3390/life15010065

Rizzo, C., Dastager, S. G., & Ay, H. (2024). Editorial: Microbial biodiversity and bioprospecting in polar ecosystems in the genomics era. Frontiers in Microbiology, 15, Article 1504105. https://doi.org/10.3389/fmicb.2024.1504105

Sakina, Z. N., Supriyadi, I., & Santoso, B. (2025). Metagenomic and functional profiling of endophytes from Indonesian medicinal plants: Potentials for sustainable bioprospecting. West Science Nature and Technology, 3(3), 144–149. https://doi.org/10.58812/wsnt.v3i03.2011

Shao, J., Peng, B., Zheng, H., Li, L., Li, D., Hu, X., Huang, L., & Tang, K. (2026). CRISPR/Cas9-mediated uORF engineering enhances tanshinone biosynthesis in Salvia miltiorrhiza. Horticulture Research, 13(1), Article uhaf249. https://doi.org/10.1093/hr/uhaf249

Urban, W., Kropacz, M., Łach, M., & Jankowska, A. (2025). CRISPR-Cas9 in the Tailoring of Genetically Engineered Animals. Current Issues in Molecular Biology, 47(5), 330. https://doi.org/10.3390/cimb47050330

Yıldırım, K., & Kavas, M. (2026). The role of CRISPR in modern plant breeding: Overcoming breeding barriers and legislative challenges through transgene-free genome editing. Genome, 69, 1–17. https://doi.org/10.1139/gen-2025-0063 Zalila-Kolsi I. (2025). Engineered bacteria as living therapeutics: Next-generation precision tools for health, industry, environment, and agriculture. AIMS microbiology, 11(4), 946–962. https://doi.org/10.3934/microbiol.2025042

Zhang, J., Sun, X., & Cao, C. (2022). Recent advances in genetically modified large-animal models of human diseases. BIO Integration, 3(4), 161–171. https://doi.org/10.15212/bioi-2022-0018

Diterbitkan

2026-10-06

Cara Mengutip

Anita Ninasari, Deny Ismail Pellu, Oktora Susanti, Kurnia Anggraini Rahmi, Meri Helsiana Mata, Hamdanul Fain, Almira Fardani Lahay, Santosa Pradana Putra Setya Negara, Triayu Rahmadiah, Muhammad Kholiqul Amiin, Leni Handayani, & Nevada JM Nanulaitta. (2026). Bioteknologi : prinsip, konsep dan aplikasi. Penerbit Kamiya Jaya Aquatic. https://kjaquatic.com/index.php/penerbitkamiyajayaaquatic/article/view/111

Artikel Serupa

51-60 dari 98

Anda juga bisa Mulai pencarian similarity tingkat lanjut untuk artikel ini.

Artikel paling banyak dibaca berdasarkan penulis yang sama